Colosse means in the bible: Phrygia is a town in the valley at the Lycus. It’s near Hierapolis and Laodicea. Also, it’s close to Ephesus and the Euphrates. Paul probably hadn’t been to this area when he wrote the epistle for the Colossians. Epaphras, possibly Timothy, were the first Christians to teach there Col. 1:1-7; 4:12-13.
(in Bible Dictionary)